Genetic analysis of liver tumorigenesis in SV40 T antigen transgenic mice implies a role for imprinted genes.

Article

Genetic analysis of liver tumorigenesis in SV40 T antigen transgenic mice implies a role for imprinted genes.

Cancer research - 15 Dec 1994

Held W A, Pazik J, O'Brien J G, Kerns K, Gobey M, Meis R, Kenny L, Rustum Y

Abstract excerpt

Liver tumors from interspecific hybrid, transgenic mice containing the SV40 early region linked to a mouse major urinary protein enhancer/promoter were analyzed for loss of heterozygosity to identify chromosomal regions which potentially contain genetic loci involved in multistep tumorigenesis. A...

Topics

Alleles
Animals
Antigens, Polyomavirus Transforming
Blotting, Southern
Breeding
Female
Gene Deletion
Liver Neoplasms
Male
Mice
Mice, Transgenic

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