Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Repression of hsp90beta gene by p53 in UV irradiation-induced apoptosis of Jurkat cells.

The Journal of biological chemistry - 8 Oct 2004

Zhang Ye, Wang Jin-Shan, Chen Li-Ling, Zhang Yong, Cheng Xiao-Kuan, Heng Feng-Yan, Wu Ning-Hua, Shen Yu-Fei

Abstract excerpt

Tumor suppressor p53 has been implicated in cell stress response and determines cell fate of either growth arrest or apoptosis. Heat shock proteins (Hsps) expressed under stress usually confer survival protection to the cell or interruption in the apoptotic pathways. Although Hsp90 can physically interact with p53, whether or not the hsp90 gene is influenced downstream of p53 in UV irradiation-induced apoptosis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotics, Antineoplastic
Share to Benzoquinones

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chloramphenicol O-Acetyltransferase

Share to HSP90 Heat-Shock Proteins

Share to Immunoprecipitation

Share to Jurkat Cells

Share to Lactams, Macrocyclic

Share to Quinones

Source

Identifiers

PMID: 15284248
DOI: 10.1074/jbc.M314213200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Repression of hsp90beta gene by p53 in UV irradiation-induced apoptosis of Jurkat cells.PMID 15284248Read ↗

Hsp90: A New Player in DNA Repair?Semantic proximity Read ↗

p53 regulates Hsp90beta during arsenite-induced cytotoxicity in glutathione-deficient cells.Semantic proximity Read ↗

DNA-Damage-Induced Alternative Splicing of p53Semantic proximity Read ↗

[The role of p53 binding site on the trans binding of p53 to Hsp90 beta gene].Semantic proximity Read ↗

Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53: implications for cancer therapy.Semantic proximity Read ↗

DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation.Semantic proximity Read ↗

Hsp90 Chaperones Wild-type p53 Tumor Suppressor ProteinSemantic proximity Read ↗

P53 plays a protective role against UV- and cisplatin-induced apoptosis in transcription-coupled repair proficient fibroblastsSemantic proximity Read ↗

Major stress protein Hsp70 interacts with NF-kB regulatory complex in human T-lymphoma cellsSemantic proximity Read ↗

Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53.Semantic proximity Read ↗

Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53.Semantic proximity Read ↗

Ionizing radiation exposure results in up-regulation of Ku70 via a p53/ataxia-telangiectasia-mutated protein-dependent mechanism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.