Article
Role of p53 in the regulation of irradiation-induced apoptosis in neuroblastoma cells.
Molecular genetics and metabolism - 1 Oct 1998
Jasty R, Lu J, Irwin T, Suchard S, Clarke M F, Castle V P
Abstract excerpt
Wild-type p53 plays a crucial role in the control of apoptosis following ionizing radiation (IR); conversely, mutant p53 is associated with IR resistance. Although wild-type p53 is expressed in virtually all neuroblastoma tumors, treatment failures secondary to inadequate local control with radio...
Topics
- Apoptosis
- Cell Nucleus
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Gene Expression
- Genes, bcl-2
- Genes, p53
- Genetic Therapy
- Humans
- Mutation
- Neuroblastoma
- Proto-Oncogene Proteins c-bcl-2
- Radiation Tolerance
- Temperature
- Transfection
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53
- bcl-X Protein