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Article

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents.

Cell - 24 Sept 1993

Lowe S W, Ruley H E, Jacks T, Housman D E

Abstract excerpt

Although the primary cellular targets of many anticancer agents have been identified, less is known about the processes leading to the selective cell death of cancer cells or the molecular basis of drug resistance. p53-deficient mouse embryonic fibroblasts were used to examine systematically the requirement for p53 in cellular sensitivity and resistance to a diverse group of anticancer agents. These results...

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PMID: 8402885
DOI: 10.1016/0092-8674(93)90719-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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