Article
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents.
Cell - 24 Sept 1993
Lowe S W, Ruley H E, Jacks T, Housman D E
Abstract excerpt
Although the primary cellular targets of many anticancer agents have been identified, less is known about the processes leading to the selective cell death of cancer cells or the molecular basis of drug resistance. p53-deficient mouse embryonic fibroblasts were used to examine systematically the...
Topics
- Adenovirus E1A Proteins
- Animals
- Antineoplastic Agents
- Apoptosis
- Cell Cycle
- Cell Line
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- DNA
- Embryo, Mammalian
- Fibroblasts
- Flow Cytometry
- Genes, p53
- Genes, ras
- Genotype
- Mice
- Oncogenes
- Transfection