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Article

Resistance to salmonellosis in the chicken is linked to NRAMP1 and TNC.

Genome research - 1 Jul 1997

Hu J, Bumstead N, Barrow P, Sebastiani G, Olien L, Morgan K, Malo D

Abstract excerpt

Natural resistance to infection with Salmonella typhimurium in mice is controlled by two major loci, Bcg and Lps, located on mouse chromosomes 1 and 4, respectively. Both Bcg and Lps exert pleiotropic effects and contribute to cytostatic/cytocidal activities of the macrophage. Bcg encodes for a membrane phosphoglycoprotein designated Nrampl (natural resistance-associated macrophage protein 1), which belongs to an...

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Source

Identifiers

PMID: 9253598
DOI: 10.1101/gr.7.7.693

Genes

TNC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Resistance to salmonellosis in the chicken is linked to NRAMP1 and TNC.PMID 9253598Read ↗

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Haplotype mapping and sequence analysis of the mouse Nramp gene predict susceptibility to infection with intracellular parasites.Semantic proximity Read ↗

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.Semantic proximity Read ↗

Genetic resistance to Salmonella infection in domestic animals.Semantic proximity Read ↗

Characterization of chicken natural resistance-associated macrophage protein encoding genes (Nramp1 and Nramp2) and association with salmonellosis resistance.Semantic proximity Read ↗

Integrated immunogenomics in the chicken: deciphering the immune response to identify disease resistance genes.Semantic proximity Read ↗

Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains.Semantic proximity Read ↗

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Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression.Semantic proximity Read ↗

Infection genomics: Nramp1 as a major determinant of natural resistance to intracellular infections.Semantic proximity Read ↗

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