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Article

Complement component C5: engineering of a mutant that is specifically cleaved by the C4-specific C1s protease.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 1995

Ogata R T, Low P J

Abstract excerpt

Previous studies showed that simply inserting or substituting a few amino acid residues immediately downstream of the proteolytic activation site in C component C3 renders that site susceptible to the C4-specific C1s protease. This report describes the results of extending those studies to the closely related component C5. We found that small changes, similar to those that made C3 susceptible to C1s, were...

Topics

Amino Acid Sequence
Animals
Complement C1 Inactivator Proteins
Complement C1s
Complement C3
Complement C4
Complement C5
Complement Factor B
Genetic Engineering
Mice
Molecular Sequence Data

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Rabbits

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Identifiers

PMID: 7650393

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7650393-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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