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Article

Functional effects of domain deletions in a multidomain serine protease, C1r.

Molecular immunology - 1 Jan 2000

Cseh S, Gál P, Sárvári M, Dobó J, Lörincz Z, Schumaker V N, Závodszky P

Abstract excerpt

The C1r subcomponent of the first component of complement is a complex, multidomain glycoprotein containing five regulatory or binding modules in addition to the serine protease domain. To reveal the functional role of the N-terminal regulatory domains, two deletion mutants of C1r were constructed. One mutant comprises the N-terminal half of domain I joined to the second half of the highly homologous domain III,...

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PMID: 8676886
DOI: 10.1016/0161-5890(95)00160-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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