Article
Functional effects of domain deletions in a multidomain serine protease, C1r.
Molecular immunology - 1 Jan 2000
Cseh S, Gál P, Sárvári M, Dobó J, Lörincz Z, Schumaker V N, Závodszky P
Abstract excerpt
The C1r subcomponent of the first component of complement is a complex, multidomain glycoprotein containing five regulatory or binding modules in addition to the serine protease domain. To reveal the functional role of the N-terminal regulatory domains, two deletion mutants of C1r were constructe...
Topics
- Amino Acid Sequence
- Animals
- Calcium
- Complement C1 Inactivator Proteins
- Complement C1r
- DNA, Complementary
- Molecular Sequence Data
- Mutation
- Recombinant Proteins
- Spodoptera
- Structure-Activity Relationship