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Article

Structural basis for activation of the complement system by component C4 cleavage.

Proceedings of the National Academy of Sciences of the United States of America - 18 Sept 2012

Kidmose Rune T, Laursen Nick S, Dobó József, Kjaer Troels R, Sirotkina Sofia, Yatime Laure, Sottrup-Jensen Lars, Thiel Steffen, Gál Péter, Andersen Gregers R

Abstract excerpt

An essential aspect of innate immunity is recognition of molecular patterns on the surface of pathogens or altered self through the lectin and classical pathways, two of the three well-established activation pathways of the complement system. This recognition causes activation of the MASP-2 or the C1s serine proteases followed by cleavage of the protein C4. Here we present the crystal structures of the 203-kDa...

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Identifiers

PMID: 22949645
DOI: 10.1073/pnas.1208031109
PMCID: PMC3458355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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