Catalytic role of a surface loop of the complement serine protease factor D.

Article

Catalytic role of a surface loop of the complement serine protease factor D.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 1995

Kim S, Narayana S V, Volanakis J E

Abstract excerpt

We have investigated the structural determinants of the unique functional properties of complement factor D by constructing and testing a series of trypsin-like mutants of the enzyme. Mutational replacement of the primary substrate-binding pocket of factor D with that of trypsin resulted in a mut...

Topics

Amino Acid Sequence
Base Sequence
Catalysis
Complement Factor B
Complement Factor D
Hemolytic Plaque Technique
Humans
Molecular Sequence Data
Mutation
Recombinant Proteins
Structure-Activity Relationship

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