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Article

Catalytic role of a surface loop of the complement serine protease factor D.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 1995

Kim S, Narayana S V, Volanakis J E

Abstract excerpt

We have investigated the structural determinants of the unique functional properties of complement factor D by constructing and testing a series of trypsin-like mutants of the enzyme. Mutational replacement of the primary substrate-binding pocket of factor D with that of trypsin resulted in a mutant (M1) with greatly reduced proteolytic activity and slightly reduced reactivity toward small thioester substrates....

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PMID: 7751649

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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