Article
Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene.
Oncogene - 1 Feb 1994
Purdie C A, Harrison D J, Peter A, Dobbie L, White S, Howie S E, Salter D M, Bird C C, Wyllie A H, Hooper M L
Abstract excerpt
In human tumourigenesis the tumour suppressor gene most commonly affected by mutation, inactivation or allele loss is p53. Loss of p53 function is associated both with failure to maintain a normal diploid status and inability to delete cells by apoptosis following DNA damage. To investigate further the role of p53 we have generated mice carrying a large deletion within the gene. All animals homozygous for this...
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