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Article

Molecular analysis reveals heterogeneity of mouse mammary tumors conditionally mutant for Brca1.

Molecular cancer - 7 Apr 2008

Wright Mollie H, Robles Ana I, Herschkowitz Jason I, Hollingshead Melinda G, Anver Miriam R, Perou Charles M, Varticovski Lyuba

Abstract excerpt

BACKGROUND: Development of therapies for patients with BRCA1 mutations has been hampered by lack of readily available in vitro and in vivo models. We recently showed that transplantation of transgenic mammary tumors as cell suspensions into naïve recipients generates reproducible tumors with remarkable stability of gene expression profile. We examined the expression profiles of original and serially transplanted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 18394172
DOI: 10.1186/1476-4598-7-29
PMCID: PMC2329667

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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