Article
P-glycoprotein is not expressed in a majority of colorectal carcinomas and is not regulated by mutant p53 in vivo.
British journal of cancer - 1 Aug 1995
De Angelis P, Stokke T, Smedshammer L, Lothe R A, Lehne G, Chen Y, Clausen O P
Abstract excerpt
Overexpression of the MDR1 product, P-glycoprotein (Pgp), has been shown to be one of the mechanisms underlying the development of multidrug resistance (MDR). Recently, one mutant p53 has been shown to stimulate the MDR1 gene promoter in vitro, whereas wild-type p53 repressed this activity. We me...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Aneuploidy
- Colorectal Neoplasms
- DNA, Neoplasm
- Drug Resistance, Multiple
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Humans
- Intestinal Mucosa
- Mutation
- Neoplasm Staging
- Tumor Suppressor Protein p53