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Article

Mutations of Ki-ras and p53 genes in colorectal cancer and their prognostic significance.

Gut - 1 Nov 1994

Morrin M, Kelly M, Barrett N, Delaney P

Abstract excerpt

The series of genetic changes leading to malignancy in colorectal cancer is well reported. This includes mutational activation of the proto-oncogene Ki-ras and mutation/deletion of the p53 tumour suppressor gene. The frequency of these mutations was investigated in a panel of 52 colorectal cancer patients using a combination of immunocytochemistry and non-radioactive, digoxigenin-labelled in situ hybridisation....

Topics

Colonic Neoplasms
Gene Expression Regulation, Neoplastic
Genes, p53
Genes, ras
Humans
Immunoenzyme Techniques
In Situ Hybridization
Mutation
Prognosis
Proto-Oncogene Mas
Rectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Suppressor Protein p53

ras Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 7828987
DOI: 10.1136/gut.35.11.1627
PMCID: PMC1375626

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7828987-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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