P53 tumour suppressor gene and germ cell neoplasia.

Abstract excerpt

P53 tumour suppressor gene mutations occur in approximately 50% of common solid tumours such as breast, colon and lung. In contrast, p53 gene mutations occur infrequently (< 3%) in germ cell tumours, even though p53 protein is expressed at high levels in the vast majority of tumour samples. P53-r...

Topics

• Animals
• Female
• Genes, Tumor Suppressor
• Germinoma
• Humans
• Male
• Mice
• Mutation
• Ovarian Neoplasms
• Testicular Neoplasms
• Tumor Suppressor Protein p53