Article
Low frequency of p53 gene mutation and protein expression in mucinous colorectal carcinomas.
Cancer letters - 5 Jun 1996
Hanski C, Tiecke F, Hummel M, Hanski M L, Ogorek D, Rolfs A, Schmitt-Gräff A, Stein H, Riecken E O
Abstract excerpt
Immunohistochemical data indicate that the frequency of p53 protein overexpression is consistently lower in the mucinous than in the non-mucinous carcinomas of the breast, ovary, pancreas and colon. This peculiar immunohistochemical behavior of the mucinous phenotype could be due to the effect of large amounts of mucus on the staining or to an actual mutation frequency difference between mucinous and non-mucinous...
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