Article
T-lymphocyte requirement for diabetes in RT6-depleted diabetes-resistant BB rats.
Diabetes - 1 Apr 1991
Woda B A, Handler E S, Greiner D L, Reynolds C, Mordes J P, Rossini A A
Abstract excerpt
Diabetes-prone (DP) BB rats develop spontaneous autoimmune insulin-dependent diabetes mellitus (IDDM). The cell populations involved in the expression of diabetes are not precisely known but probably include natural killer (NK) cells, macrophages, and T lymphocytes. Because the DP rat has few lymphocytes of the CD5+/CD+ phenotype, cytotoxic T lymphocytes (Tc) are not believed to be important in the process....
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