Article
Biological effect of varying peptide binding affinity to the BoLA-DRB3*2703 allele.
Genetics, selection, evolution : GSE - 1 Jan 2003
Alizadeh Zahra, Karrow Niel, Mallard Bonnie A
Abstract excerpt
MHC class I and II molecules are immunoregulatory cell surface glycoproteins, which selectively bind to and present antigenic peptides to T-lymphocytes. Murine and human studies show that variable peptide binding affinity to MHC II molecules influences Th1/Th2 responses by inducing distinctive cytokine expression. To examine the biological effects of peptide binding affinity to bovine MHC (BoLA), various self...
Topics
- Alleles
- Animals
- Binding, Competitive
- Biotinylation
- Blotting, Western
- Cattle
- Cell Division
- Fluoresceins
- Histocompatibility Antigens Class II
- Ovalbumin
- Peptide Fragments
- Peptides
- Protein Binding
- Succinimides
- T-Lymphocytes