Article
The specificity and efficiency of endogenous peptides in the induction of HLA class I alpha chain refolding.
European journal of immunology - 1 Aug 1992
Tanigaki N
Abstract excerpt
The specificity and efficiency of endogenous peptides in the HLA class I binding have been investigated by the use of a simple procedure that is based on the serological detection of the folding of HLA class I alpha chains that is induced by the binding to specific peptides in the presence of beta 2 microglobulin. HLA class I proteins were solubilized with a nonionic detergent from cultured HLA homozygous B...
Topics
- Alleles
- Histocompatibility Antigens Class I
- Humans
- Hydrogen-Ion Concentration
- Peptides
- Protein Conformation
- Protein Denaturation
- beta 2-Microglobulin