High-affinity binding of an influenza hemagglutinin-derived peptide to purified HLA-DR.

Article

High-affinity binding of an influenza hemagglutinin-derived peptide to purified HLA-DR.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1990

Roche P A, Cresswell P

Abstract excerpt

Immunogenic peptides have been shown to bind detergent-solubilized class II (Ia) molecules from mice. In this investigation, we report that highly purified HLA-DR (DR) molecules in detergent solution are capable of binding a synthetic peptide (HAp) derived from the influenza hemagglutinin sequenc...

Topics

Alleles
HLA-DR Antigens
Hemagglutinins, Viral
Humans
In Vitro Techniques
Influenza A virus
Kinetics
Molecular Weight
Oligopeptides
Protein Binding

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