Insertion of an uncharged polypeptide into the mitochondrial inner membrane does not require a trans-bilayer electrochemical potential: effects of positive charges.

doi:10.1016/0005-2736(95)00088-k

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Article

Insertion of an uncharged polypeptide into the mitochondrial inner membrane does not require a trans-bilayer electrochemical potential: effects of positive charges.

Biochimica et biophysica acta - 26 Jul 1995

McBride H M, Silvius J R, Shore G C

Abstract excerpt

Mitochondria with a ruptured outer membrane exhibited impaired import into this membrane of an outer membrane fusion protein containing the signal-anchor sequence of Mas70p. However, the Mas70p signal-anchor efficiently targeted and inserted the protein directly into exposed regions of the inner membrane. Import into the inner membrane was dependent on delta psi and this dependence was due to the presence of the...

Topics

Amino Acid Sequence
Animals
Biological Transport
Electrochemistry
Fungal Proteins
Intracellular Membranes
Lipid Bilayers
Male
Membrane Proteins
Mitochondria, Liver
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Peptides

Rats

Rats, Sprague-Dawley

Receptors, Cell Surface

Recombinant Fusion Proteins

Source

Open in PubMed

Identifiers

PMID: 7632709
DOI: 10.1016/0005-2736(95)00088-k

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7632709-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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