Article
Evidence for Amino Acid Snorkeling from a High-Resolution, In Vivo Analysis of Fis1 Tail-Anchor Insertion at the Mitochondrial Outer Membrane.
Genetics - 1 Feb 2017
Keskin Abdurrahman, Akdoğan Emel, Dunn Cory D
Abstract excerpt
Proteins localized to mitochondria by a carboxyl-terminal tail anchor (TA) play roles in apoptosis, mitochondrial dynamics, and mitochondrial protein import. To reveal characteristics of TAs that may be important for mitochondrial targeting, we focused our attention upon the TA of the Saccharomyces cerevisiae Fis1 protein. Specifically, we generated a library of Fis1p TA variants fused to the Gal4 transcription...
Topics
- Mitochondrial Membranes
- Mitochondrial Proteins
- Mutation
- Protein Domains
- Protein Sorting Signals
- Protein Transport
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins