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Article

Function of positive charges following signal-anchor sequences during translocation of the N-terminal domain.

The Journal of biological chemistry - 13 Jan 2006

Kida Yuichiro, Morimoto Fumiko, Mihara Katsuyoshi, Sakaguchi Masao

Abstract excerpt

In topogenesis of membrane proteins on the endoplasmic reticulum, the orientation of the hydrophobic transmembrane (TM) segment is influenced by the charge of the flanking amino acid residues. We assessed the function of the positive charges downstream of the hydrophobic segment using synaptotagmin II. The positive charges were systematically replaced with non-charged residues. Although the original TM segment...

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Identifiers

PMID: 16291756
DOI: 10.1074/jbc.M506613200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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