Article
Multiple functions of tail-anchor domains of mitochondrial outer membrane proteins.
FEBS letters - 18 Dec 2003
Habib Shukry J, Vasiljev Andreja, Neupert Walter, Rapaport Doron
Abstract excerpt
Tail-anchored proteins form a distinct class of membrane proteins that have a single membrane anchor sequence at their C-terminus, the tail-anchor. Their N-terminal portion is exposed to the cytosol. We have studied the roles of tail-anchor domains of proteins residing in the mitochondrial outer membrane. Four distinct functions of the tail-anchor domain were identified. First, the domain mediates the targeting...
Topics
- Amino Acid Sequence
- Cytosol
- Fungal Proteins
- Genetic Complementation Test
- Intracellular Membranes
- Membrane Proteins
- Mitochondrial Proteins
- Molecular Sequence Data
- Phenotype
- Protein Sorting Signals
- Protein Structure, Tertiary
- Recombinant Fusion Proteins
- Saccharomyces cerevisiae