Article
Multiple functions of tail-anchor domains of mitochondrial outer membrane proteins.
FEBS letters - 18 Dec 2003
Habib Shukry J, Vasiljev Andreja, Neupert Walter, Rapaport Doron
Abstract excerpt
Tail-anchored proteins form a distinct class of membrane proteins that have a single membrane anchor sequence at their C-terminus, the tail-anchor. Their N-terminal portion is exposed to the cytosol. We have studied the roles of tail-anchor domains of proteins residing in the mitochondrial outer membrane. Four distinct functions of the tail-anchor domain were identified. First, the domain mediates the targeting...
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