Article
Juxtaposition of signal-peptide charge and core region hydrophobicity is critical for functional signal peptides.
Archives of microbiology - 1 Oct 2002
Rusch Sharyn L, Mascolo Cynthia L, Kebir Maha O, Kendall Debra A
Abstract excerpt
In Escherichia coli, exported proteins are synthesized as precursors containing an amino-terminal signal peptide which directs transport through the translocase to the proper destination. We have constructed a series of signal peptide mutants, incorporating linker sequences of varying lengths between the amino-terminal charge and core region hydrophobicity, to examine the requirement for the juxtaposition of...
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