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Article

Two distinct membrane potential-dependent steps drive mitochondrial matrix protein translocation.

The Journal of cell biology - 2 Jan 2017

Schendzielorz Alexander Benjamin, Schulz Christian, Lytovchenko Oleksandr, Clancy Anne, Guiard Bernard, Ieva Raffaele, van der Laan Martin, Rehling Peter

Abstract excerpt

Two driving forces energize precursor translocation across the inner mitochondrial membrane. Although the membrane potential (Δψ) is considered to drive translocation of positively charged presequences through the TIM23 complex (presequence translocase), the activity of the Hsp70-powered import motor is crucial for the translocation of the mature protein portion into the matrix. In this study, we show that...

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Source

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Identifiers

PMID: 28011846
DOI: 10.1083/jcb.201607066
PMCID: PMC5223606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Two distinct membrane potential-dependent steps drive mitochondrial matrix protein translocation.PMID 28011846Read ↗

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