Mismatch repair deficiency in phenotypically normal human cells.

doi:10.1126/science.7632227

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Article

Mismatch repair deficiency in phenotypically normal human cells.

Science (New York, N.Y.) - 5 May 1995

Parsons R, Li G M, Longley M, Modrich P, Liu B, Berk T, Hamilton S R, Kinzler K W, Vogelstein B

Abstract excerpt

Tumor cells in patients with hereditary nonpolyposis colorectal cancer (HNPCC) are characterized by a genetic hypermutability caused by defects in DNA mismatch repair. A subset of HNPCC patients was found to have widespread mutations not only in their tumors, but also in their non-neoplastic cell...

Topics

Base Sequence
Cell Line, Transformed
Clone Cells
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Repair
DNA, Satellite
Humans
Intestinal Mucosa
Lymphocytes
Molecular Sequence Data
Mutation
Phenotype
Repetitive Sequences, Nucleic Acid

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Identifiers

PMID: 7632227
DOI: 10.1126/science.7632227

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7632227-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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