Article
Patterns of mutation in cancer cells.
Cancer surveys - 1 Jan 1996
Meuth M
Abstract excerpt
The discovery of powerful mutator phenotypes in a subset of colon cancers provides direct support for the hypothesis that destabilization of replication fidelity and repair drive the accumulation of mutations in tumour suppressor or proto-oncogenes. Nevertheless, many important questions remain....
Topics
- Animals
- Chromosome Deletion
- Colonic Neoplasms
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Repair
- DNA Replication
- Gene Rearrangement
- Genes, Regulator
- Humans
- Microsatellite Repeats
- Mutagenesis
- Phenotype
- Tumor Cells, Cultured