Article
Patterns of mutation in cancer cells.
Cancer surveys - 1 Jan 1996
Meuth M
Abstract excerpt
The discovery of powerful mutator phenotypes in a subset of colon cancers provides direct support for the hypothesis that destabilization of replication fidelity and repair drive the accumulation of mutations in tumour suppressor or proto-oncogenes. Nevertheless, many important questions remain. The tumour cell lines in which these mutator genes were characterized have many other mutations that may contribute to...
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