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Article

Methylation tolerance in mismatch repair proficient cells with low MSH2 protein level.

Oncogene - 25 Apr 2002

Claij Nanna, Te Riele Hein

Abstract excerpt

Loss of DNA mismatch repair has been found in tumors associated with the familial cancer predisposition syndrome HNPCC (hereditary non-polyposis colorectal cancer) and a subset of sporadic cancers. MSH2 deficiency abolishes the action of the mismatch repair system, resulting in a phenotype which is characterized by an increased accumulation of base substitutions and frameshifts, enhanced recombination between...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11973647
DOI: 10.1038/sj.onc.1205395

Genes

MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Methylation tolerance in mismatch repair proficient cells with low MSH2 protein level.PMID 11973647Read ↗

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MSH2 and MSH6 as size dependent cellular determinants for prime editing in human embryonic stem cellsSemantic proximity Read ↗

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Mismatch repair and differential sensitivity of mouse and human cells to methylating agents.Semantic proximity Read ↗

Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells.Semantic proximity Read ↗

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