CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.

Article

CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.

Cancer research - 15 Dec 1994

Schmidt E E, Ichimura K, Reifenberger G, Collins V P

Abstract excerpt

Forty-six glioblastomas, 16 anaplastic astrocytomas, and 8 astrocytomas were studied for the loss of the CDKN2 (p16/MTS1) gene on 9p. The CDKN2 locus was homozygously deleted in 19 of 46 glioblastomas (41%) and 1 allele was lost in an additional 13 cases (28%). The deleted regions were limited ce...

Topics

Alleles
Astrocytoma
Base Sequence
Chromosomes, Human, Pair 9
Gene Amplification
Gene Deletion
Glioblastoma
Humans
Molecular Sequence Data

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