Article
Galpha16 activates Ras by forming a complex with tetratricopeptide repeat 1 (TPR1) and Son of Sevenless (SOS).
Cellular signalling - 1 Oct 2010
Liu Andrew M F, Lo Rico K H, Lee Maggie M K, Wang Yingchun, Yeung Wendy W S, Ho Maurice K C, Su Yan, Ye Richard D, Wong Yung H
Abstract excerpt
Many G protein-coupled receptors (GPCRs) are known to modulate cell growth and differentiation by stimulating the extracellular signal-regulated protein kinases (ERKs). In growth factor signaling, ERKs are typically stimulated through an elaborate network of modules consisting of adaptors, protein kinases, and the small GTPase Ras. The mechanism by which G protein signals tap into the ERK signaling pathway has...
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