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Article

Analysis of inherited genetic variants in ret proto-oncogene of Brazilian patients with apparently sporadic medullary thyroid carcinoma.

Thyroid : official journal of the American Thyroid Association - 1 Jan 2006

Guerrero I M, Pessoa C H C, Olmedo D B, Pontes E R P, Matos L C, Tilli T M, Barcinski M A, Gimba E R P

Abstract excerpt

Mutations in different exons of ret proto-oncogene are responsible for the development of medullary thyroid carcinoma (MTC). The mutations can occur as sporadic or as part of multiple endocrine neoplasia (MEN) type 2 hereditary syndromes. Here we report the first focused study of sporadic MTC in Brazilian patients regarding clinical and molecular analysis of ret proto-oncogene. Our study seeks to estimate the...

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PMID: 16487008
DOI: 10.1089/thy.2006.16.9

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