Article
Tetracycline-controlled transgenic targeting from the SCL locus directs conditional expression to erythrocytes, megakaryocytes, granulocytes, and c-kit-expressing lineage-negative hematopoietic cells.
Blood - 1 Sept 2006
Bockamp Ernesto, Antunes Cecilia, Maringer Marko, Heck Rosario, Presser Katrin, Beilke Sven, Ohngemach Svetlana, Alt Rudiger, Cross Michael, Sprengel Rolf, Hartwig Udo, Kaina Bernd, Schmitt Steffen, Eshkind Leonid
Abstract excerpt
The stem cell leukemia gene SCL, also known as TAL-1, encodes a basic helix-loop-helix transcription factor expressed in erythroid, myeloid, megakaryocytic, and hematopoietic stem cells. To be able to make use of the unique tissue-restricted and spatio-temporal expression pattern of the SCL gene, we have generated a knock-in mouse line containing the tTA-2S tetracycline transactivator under the control of SCL...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.