Article
SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish.
Genes & development - 1 Mar 1998
Liao E C, Paw B H, Oates A C, Pratt S J, Postlethwait J H, Zon L I
Abstract excerpt
SCL/Tal-1 is a transcription factor necessary for hematopoietic stem cell differentiation. Although SCL is also expressed in endothelial and neural progenitors, SCL function in these cells remains unknown. In the zebrafish mutant cloche (clo), SCL expression is nearly abolished in hematopoietic a...
Topics
- Amino Acid Sequence
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Chromosome Mapping
- Conserved Sequence
- DNA-Binding Proteins
- Embryo, Nonmammalian
- Endothelium, Vascular
- Gene Expression Regulation, Developmental
- Hematopoietic Stem Cells
- Molecular Sequence Data
- Mutation
- Proto-Oncogene Proteins