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Article

Cdk2-dependent phosphorylation of p21 regulates the role of Cdk2 in cisplatin cytotoxicity.

American journal of physiology. Renal physiology - 1 May 2011

Hodeify Rawad, Tarcsafalvi Adel, Megyesi Judit, Safirstein Robert L, Price Peter M

Abstract excerpt

Cisplatin cytotoxicity is dependent on cyclin-dependent kinase 2 (Cdk2) activity in vivo and in vitro. We found that an 18-kDa protein identified by mass spectrometry as p21(WAF1/Cip1) was phosphorylated by Cdk2 starting 12 h after cisplatin exposure. The analysis showed it was phosphorylated at serine 78, a site not previously identified. The adenoviral transduction of p21 before cisplatin exposure protects from...

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Identifiers

PMID: 21325496
DOI: 10.1152/ajprenal.00507.2010
PMCID: PMC3094048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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