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Article

p53 is associated with p34cdc2 in transformed cells.

The EMBO journal - 1 Sept 1990

Milner J, Cook A, Mason J

Abstract excerpt

The normal functioning of p53 is thought to involve p53 target proteins. We have previously identified a cellular 35 kd protein associated with p53 and now report evidence identifying this 35 kd protein as p34cdc2, product of the cell cycle control cdc2 gene. The association between p53 and p34cdc2 was detected in SV3T3 and T3T3 cell lines, both expressing the wild-type p53 phenotype, and in 3T3tx cells,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 2167834
DOI: 10.1002/j.1460-2075.1990.tb07478.x
PMCID: PMC552003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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p53 is associated with p34cdc2 in transformed cells.PMID 2167834Read ↗

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Downregulation of the cdc2/cyclin B protein kinase activity by binding of p53 to p34(cdc2).Semantic proximity Read ↗

Partially transformed T3T3 cells express high levels of mutant p53 in the 'wild-type' immunoreactive form with defective oligomerization.Semantic proximity Read ↗

Simian virus 40 large T antigen affects the Saccharomyces cerevisiae cell cycle and interacts with p34CDC28.Semantic proximity Read ↗

Mapping of the interaction sites of the growth suppressor protein p53 with the regulatory beta-subunit of protein kinase CK2.Semantic proximity Read ↗

A dominant negative allele of p34cdc2 shows altered phosphoamino acid content and sequesters p56cdc13 cyclin.Semantic proximity Read ↗

Human p53 and CDC2Hs genes combine to inhibit the proliferation of Saccharomyces cerevisiae.Semantic proximity Read ↗

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