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Article

Introduction of wild-type p53 in a human ovarian cancer cell line not expressing endogenous p53.

Nucleic acids research - 25 Mar 1994

Vikhanskaya F, Erba E, D'Incalci M, Broggini M

Abstract excerpt

Utilizing a temperature sensitive p53 mutant (pLTRp53cGval135) which expresses mutant p53 at 37 degrees C and a wild-type like p53 at 32 degrees C, we transfected a human ovarian cancer cell line (SKOV3) which does not express endogenous p53. Among the different clones obtained, we selected three clones. Two were obtained from simultaneous transfection of p53 and neomycin resistance expression plasmids (SK23a and...

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Identifiers

PMID: 8152906
DOI: 10.1093/nar/22.6.1012
PMCID: PMC307923

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