Article
The C-terminus of mutant p53 is necessary for its ability to interfere with growth arrest or apoptosis.
Oncogene - 9 Aug 2001
Sigal A, Matas D, Almog N, Goldfinger N, Rotter V
Abstract excerpt
The ability to suppress wild type p53-independent apoptosis may play an important role in the oncogenicity of p53 mutant proteins. However, structural elements necessary for this activity are unknown. Furthermore, it is unclear whether this mutant p53 mediated inhibition is specific to the apoptotic pathway or a more general suppression of the cellular response to stress. We observed that an unmodified C-terminus...
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