Dependence of globin gene expression in mouse erythroleukemia cells on the NF-E2 heterodimer.

doi:10.1128/MCB.15.8.4640

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Article

Dependence of globin gene expression in mouse erythroleukemia cells on the NF-E2 heterodimer.

Molecular and cellular biology - 1 Aug 1995

Kotkow K J, Orkin S H

Abstract excerpt

High-level, tissue-specific expression of the beta-globin genes requires the presence of an upstream locus control region (LCR). The overall enhancer activity of the beta-globin complex LCR (beta-LCR) is dependent on the integrity of the tandem NF-E2 sites of HS-2. The NF-E2 protein which binds these sites is a heterodimeric basic leucine zipper protein composed of a tissue-specific subunit, p45 NF-E2, and a...

Topics

Animals
Base Sequence
DNA-Binding Proteins
Erythroid-Specific DNA-Binding Factors
Gene Expression Regulation, Neoplastic
Globins
Leucine Zippers
Leukemia, Erythroblastic, Acute
MafK Transcription Factor
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

NF-E2 Transcription Factor

NF-E2 Transcription Factor, p45 Subunit

Protein Conformation

Recombinant Proteins

Regulatory Sequences, Nucleic Acid

Sequence Deletion

Source

Open in PubMed Open full text

Identifiers

PMID: 7623856
DOI: 10.1128/MCB.15.8.4640
PMCID: PMC230705

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7623856-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Dependence of globin gene expression in mouse erythroleukemia cells on the NF-E2 heterodimer.PMID 7623856Read ↗

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Conserved elements containing NF-E2 and tandem GATA binding sites are required for erythroid-specific chromatin structure reorganization within the human beta-globin locus control region.Semantic proximity Read ↗

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Reconstitution of Human β-Globin Locus Control Region Hypersensitive Sites in the Absence of Chromatin AssemblySemantic proximity Read ↗

The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus.Semantic proximity Read ↗

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