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Article

Transcriptional regulation of the murine erythroid-specific 5-aminolevulinate synthase gene.

Gene - 18 Apr 2000

Kramer M F, Gunaratne P, Ferreira G C

Abstract excerpt

5-Aminolevulinate synthase (ALAS) catalyzes the first step of the heme biosynthetic pathway in mammalian cells. Separate genes encode the two isoforms: ubiquitously expressed ALAS (ALAS1) and erythroid-specific ALAS (ALAS2). Transcription of the ALAS2 gene is only activated during erythroid cell differentiation. This stimulation allows for the formation of hemoglobin-specific heme. The 5'-flanking region of the...

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Source

Identifiers

PMID: 10773455
DOI: 10.1016/s0378-1119(00)00103-7

Genes

ALAS2
ALAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Transcriptional regulation of the murine erythroid-specific 5-aminolevulinate synthase gene.PMID 10773455Read ↗

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