Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus.

Molecular cell - 1 Oct 1998

Epner E, Reik A, Cimbora D, Telling A, Bender M A, Fiering S, Enver T, Martin D I, Kennedy M, Keller G, Groudine M

Abstract excerpt

The murine beta-globin locus control region (LCR) was deleted from its native chromosomal location. The approximately 25 kb deletion eliminates all sequences and structures homologous to those defined as the human LCR. In differentiated ES cells and erythroleukemia cells containing the LCR-deleted chromosome, DNasel sensitivity of the beta-globin domain is established and maintained, developmental regulation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Deletion
Share to Gene Expression

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Globins

Share to Phenotype

Share to Protein Conformation

Share to Transcriptional Activation

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 9809066
DOI: 10.1016/s1097-2765(00)80144-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus.PMID 9809066Read ↗

The higher structure of chromatin in the LCR of the beta-globin locus changes during development.Semantic proximity Read ↗

Deletion of the core region of 5' HS2 of the mouse beta-globin locus control region reveals a distinct effect in comparison with human beta-globin transgenes.Semantic proximity Read ↗

Synergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5'HS3 deletion mutations: implication for LCR chromatin architecture.Semantic proximity Read ↗

The murine beta-globin locus control region regulates the rate of transcription but not the hyperacetylation of histones at the active genes.Semantic proximity Read ↗

Reconstitution of Human β-Globin Locus Control Region Hypersensitive Sites in the Absence of Chromatin AssemblySemantic proximity Read ↗

The mouse beta-globin locus control region: hypersensitive sites 3 and 4.Semantic proximity Read ↗

Heterozygosity for deletion of hypersensitive site 3 in the human locus control region has an unexpected minor effect on red cell phenotype.Semantic proximity Read ↗

The human β‐globin locus control regionSemantic proximity Read ↗

Conserved elements containing NF-E2 and tandem GATA binding sites are required for erythroid-specific chromatin structure reorganization within the human beta-globin locus control region.Semantic proximity Read ↗

Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region.Semantic proximity Read ↗

Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription.Semantic proximity Read ↗

Factors binding a non-classical Cis-element prevent heterochromatin effects on locus control region activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.