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Article

Contribution of p53 to metastasis.

Cancer discovery - 1 Apr 2014

Powell Emily, Piwnica-Worms David, Piwnica-Worms Helen

Abstract excerpt

UNLABELLED: The tumor suppressor p53 is lost or mutated in about half of all human cancers, and in those tumors in which it is wild-type, mechanisms exist to prevent its activation. p53 loss not only prevents incipient tumor cells from undergoing oncogene-induced senescence and apoptosis, but also perturbs cell-cycle checkpoints. This enables p53-deficient tumor cells with DNA damage to continue cycling, creating...

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Source

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Identifiers

PMID: 24658082
DOI: 10.1158/2159-8290.CD-13-0136
PMCID: PMC4063123

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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