Article
p53 mutation in the genesis of metastasis.
Sub-cellular biochemistry - 1 Jan 2014
Yeudall W A
Abstract excerpt
Development of metastatic cancer is a complex series of events that includes genesis of tumor-related vascular and lymphatic systems, enhanced cellular motility, and the capacity to invade and survive at distant sites, as well as evasion of host defences. The wild-type p53 protein plays key roles in controlling these facets of tumor progression, and loss of normal p53 function can be sufficient to predispose...
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