Absence of p53 germ-line mutations in bilateral breast cancer patients.

doi:10.1007/BF00217135

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Article

Absence of p53 germ-line mutations in bilateral breast cancer patients.

Human genetics - 1 May 1992

Lidereau R, Soussi T

Abstract excerpt

The cause of Li-Fraumeni syndrome, a rare group syndrome of familial cancers, has recently been identified. Patients with this inherited condition are highly susceptible to specific neoplasms, including early-onset breast cancers. The available evidence links Li-Fraumeni syndrome to inherited mut...

Topics

Adult
Aged
Aged, 80 and over
Base Sequence
Breast Neoplasms
DNA, Single-Stranded
Exons
Female
Genes, p53
Humans
Li-Fraumeni Syndrome
Middle Aged
Molecular Sequence Data
Mutation
Neoplasms, Multiple Primary
Neoplasms, Second Primary
Nucleic Acid Conformation
Polymorphism, Genetic

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