Article
Absence of p53 germ-line mutations in bilateral breast cancer patients.
Human genetics - 1 May 1992
Lidereau R, Soussi T
Abstract excerpt
The cause of Li-Fraumeni syndrome, a rare group syndrome of familial cancers, has recently been identified. Patients with this inherited condition are highly susceptible to specific neoplasms, including early-onset breast cancers. The available evidence links Li-Fraumeni syndrome to inherited mutations of the tumor suppressor gene p53. Moreover, somatically acquired p53 mutations and gene deletions are common...
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