Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

No germline TP53 mutations detected in familial and bilateral testicular cancer.

Genes, chromosomes & cancer - 1 Feb 1993

Heimdal K, Lothe R A, Lystad S, Holm R, Fosså S D, Børresen A L

Abstract excerpt

Mutations in the TP53 gene are considered to be among the most common genetic alterations in human cancers. Both somatic and germline mutations have been found. Using polymerase chain reaction (PCR), constant denaturant gel electrophoresis (CDGE), and denaturing gradient gel electrophoresis (DGGE), we have examined 32 patients with bilateral and familial germ cell tumors (GCT) and two patients with sporadic GCT...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 17
Share to DNA Mutational Analysis
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, p53

Share to Genetic Predisposition to Disease

Share to Neoplasms, Multiple Primary

Share to Polymerase Chain Reaction

Share to Sequence Deletion

Source

Identifiers

PMID: 7680893
DOI: 10.1002/gcc.2870060205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

No germline TP53 mutations detected in familial and bilateral testicular cancer.PMID 7680893Read ↗

Mutations of the p53 gene do not occur in testis cancer.Semantic proximity Read ↗

Absence of p53 germ-line mutations in bilateral breast cancer patients.Semantic proximity Read ↗

Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of literature.Semantic proximity Read ↗

Mutations of c-kit gene in bilateral testicular germ cell tumours in Japan.Semantic proximity Read ↗

Mutations of the p53 gene are not detectable in human testicular tumors.Semantic proximity Read ↗

WT1 gene analysis in sporadic early-onset and bilateral wilms tumor patients without associated abnormalities.Semantic proximity Read ↗

Increased p53 protein does not correlate to p53 gene mutations in microdissected human testicular germ cell tumors.Semantic proximity Read ↗

Absence of germline and somatic p53 alterations in children with sporadic brain tumors.Semantic proximity Read ↗

BCL10 is not a major target for frequent loss of 1p in testicular germ cell tumors.Semantic proximity Read ↗

Immunohistochemical and mutational analysis of the p53 tumour suppressor gene and the bcl-2 oncogene in primary testicular germ cell tumours.Semantic proximity Read ↗

The role of p53 mutations in bilateral breast carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.