Article
No germline TP53 mutations detected in familial and bilateral testicular cancer.
Genes, chromosomes & cancer - 1 Feb 1993
Heimdal K, Lothe R A, Lystad S, Holm R, Fosså S D, Børresen A L
Abstract excerpt
Mutations in the TP53 gene are considered to be among the most common genetic alterations in human cancers. Both somatic and germline mutations have been found. Using polymerase chain reaction (PCR), constant denaturant gel electrophoresis (CDGE), and denaturing gradient gel electrophoresis (DGGE...
Topics
- Carcinoma in Situ
- Chromosomes, Human, Pair 17
- DNA Mutational Analysis
- DNA, Neoplasm
- Dysgerminoma
- Genes, p53
- Genetic Predisposition to Disease
- Humans
- Male
- Neoplasms, Multiple Primary
- Neoplastic Syndromes, Hereditary
- Polymerase Chain Reaction
- Sequence Deletion
- Teratoma
- Testicular Neoplasms