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Article

T cell proliferative response induced by DNA topoisomerase I in patients with systemic sclerosis and healthy donors.

1 Jul 1995

Abstract excerpt

The in vitro T cell proliferative response to DNA topoisomerase I (topo I) was examined in 26 systemic sclerosis (SSc) patients with anti-topo I antibody, 10 SSc patients without anti-topo I antibody, and 21 healthy donors. Using recombinant fusion proteins encompassing the entire human topo I amino acid sequence, a topo I-specific proliferative response was detected in PBMC cultures from 25 (96%) anti-topo...

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PMID: 7615831
DOI: 10.1172/jci118071

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