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Article

Mapping of the immunodominant T cell epitopes of the protein topoisomerase I.

Annals of the rheumatic diseases - 1 Aug 2004

Veeraraghavan S, Renzoni E A, Jeal H, Jones M, Hammer J, Wells A U, Black C M, Welsh K I, du Bois R M

Abstract excerpt

OBJECTIVES: To identify the immunodominant T cell epitopes of the topoisomerase I protein in patients with systemic sclerosis (SSc) and control subjects, using computational analysis software (TEPITOPE) and T cell proliferation assays. METHODS: Six oligopeptides, predicted by TEPITOPE software as potential topoisomerase protein epitopes, were used to perform T cell proliferation assays in 21 patients with SSc and...

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Share to HLA-D Antigens
Share to DNA Topoisomerases, Type I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitope Mapping

Share to Epitopes, T-Lymphocyte

Share to Histocompatibility Testing

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Share to Scleroderma, Systemic

Source

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Identifiers

PMID: 15249326
DOI: 10.1136/ard.2003.008037
PMCID: PMC1755092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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