Article
Human Leukocyte Antigen and Systemic Sclerosis in Japanese: The Sign of the Four Independent Protective Alleles, DRB1*13:02, DRB1*14:06, DQB1*03:01, and DPB1*02:01.
PloS one - 1 Jan 2016
Furukawa Hiroshi, Oka Shomi, Kawasaki Aya, Shimada Kota, Sugii Shoji, Matsushita Takashi, Hashimoto Atsushi, Komiya Akiko, Fukui Naoshi, Kobayashi Kouji, Osada Atsumu, Ihata Atsushi, Kondo Yuya, Nagai Tatsuo, Setoguchi Keigo, Okamoto Akiko, Okamoto Akira, Chiba Noriyuki, Suematsu Eiichi, Kono Hajime, Katayama Masao, Hirohata Shunsei, Sumida Takayuki, Migita Kiyoshi, Hasegawa Minoru, Fujimoto Manabu, Sato Shinichi, Nagaoka Shouhei, Takehara Kazuhiko, Tohma Shigeto, Tsuchiya Naoyuki
Abstract excerpt
OBJECTIVE: Several studies on associations between human leukocyte antigen (HLA) allele frequencies and susceptibility to systemic sclerosis (SSc) have been reported. Anti-centromere antibodies (ACA) and anti-topoisomerase I antibodies (ATA) are found in SSc patients. Here, we sought to identify HLA alleles associated with SSc in Japanese, and explored their associations with SSc phenotypes including the presence...
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