Article

Enhanced recognition of topoisomerase 1 upon DNA binding by a subset of anti-topoisomerase 1 autoantibodies in systemic sclerosis

2025-05-29

Abstract excerpt

<h4>Objectives</h4> Systemic sclerosis (SSc) is a deleterious disease. Its clinical management is complicated by strong interpatient heterogeneity. Progressive organ fibrosis is linked to autoantibodies against topoisomerase 1 (TOP1). Here, we hypothesized that the molecular interaction between anti-TOP1 autoantibodies (ATAs) and TOP1 could be a relevant determinant of SSc pathogenesis. DNA binding by TOP1 might...

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Literature Corpus work: dad4ce02-0eaf-5120-84c9-a7e1983b1dc3
DOI: 10.1101/2025.05.26.656088

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