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Article

Autoreactive T cells to topoisomerase I in monozygotic twins discordant for systemic sclerosis.

Arthritis and rheumatism - 1 Jul 2001

Kuwana M, Feghali C A, Medsger T A, Wright T M

Abstract excerpt

OBJECTIVE: To examine T and B cell responses to topoisomerase I (topo I) in a monozygotic twin pair discordant for systemic sclerosis (SSc). METHODS: The peripheral blood T cell proliferative responses induced by topo I and in vitro anti-topo I antibody production in cultures of T and B cells were examined in an SSc patient with serum anti-topo I antibody and in her healthy monozygotic twin. Topo I-reactive T...

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Source

Identifiers

PMID: 11465716
DOI: 10.1002/1529-0131(200107)44:7<1654::AID-ART288>3.0.CO;2-O

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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