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Article

N-acetylbenzidine and N,N'-diacetylbenzidine formation by rat and human liver slices exposed to benzidine.

Carcinogenesis - 1 Jul 1995

Lakshmi V M, Bell D A, Watson M A, Zenser T V, Davis B B

Abstract excerpt

The extent to which N-acetylbenzidine and N,N'-diacetylbenzidine are formed may influence benzidine-induced carcinogenesis. This study compared the formation of these metabolites by rat and human liver slices. The relationship between the NAT2 genotype and the formation of these acetylated products was also evaluated in humans. In rat liver slices incubated with 0.05 mM [3H]benzidine for 1 h (n = 3),...

Topics

Aged
Animals
Base Sequence
Benzidines
Female
Genotype
Humans
Inactivation, Metabolic
Liver
Male
Middle Aged
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Rats

Rats, Inbred F344

Tritium

Source

Identifiers

PMID: 7614690
DOI: 10.1093/carcin/16.7.1565

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7614690-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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